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October 2015

Volume 1 Issue 2

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 Review Article

 Management of Neurological Adverse Events Associated with Immunotherapy and A Possible Algorithm for Clinical Management

 Timothy Allen, MD, Ph.D*, Giridhar M.N.V, MD,MBA*, Ghazaleh Shoja E Razavi MD

Different neurological disorders, including alterations of peripheral nerves, multiple sclerosis (MS), optic neuritis (ON), acute transverse myelitis (ATM) and posterior reversible encephalopathy syndrome (PRES) can be associated with some types of immunotherapy. Likewise, anti-tumor necrosis factor alpha (TNF-a) treatments for autoimmune diseases such as rheumatoid arthritis (RA), psoriatic arthritis, psoriasis, ankylosing spondylitis (AS), juvenile chronic arthritis, and Crohn’s disease have also associated with neurological disorders.

                                                                                                                                                             

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 Review Article

 In silico Prediction of Immunogenic T Cell Epitopes of Leishmania donovani donovani GP63 Protein: an Alternative Approach for Anti-parasite Vaccine Development

Mona E. E. Elfaki, Anne S. De Groot, Andres H. Gutierrez, Brema M. Younis, Rayan Tassone, Francis Terry, Ahmed M. Musa, Ahmed M. Elhassan, Eltahir A. G. Khalil*

Visceral leishmaniasis (VL) is a major parasitic childhood disease in sub-Saharan Africa. Expensive and toxic anti-leishmanial drugs are current control methods. Safe, effective and cheap vaccines are potentially powerful strategies to control VL. Traditional vaccine development techniques have failed to deliver an effective vaccine. Leishmania vaccine development may benefit from immunoinformatics tools. This paper describes an improved in silico prediction method for immunogenic Leishmania donovani donovani GP63 protein T cell epitopes as VL candidate vaccines.

                                                                                                                                

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Research Article

Rubella and Congenital Rubella Syndrome Elimination, the Oman Experience

Salah T. Al Awaidy*, Salim Al Mahrouqi, Hosammudin Mohammed Nwar Al Den, Suleiman Al Busaidi, Badder Al Rawahi, Maryam Al Shaibi, Idris Al Obaidani, Said Al Baqlani

Visceral leishmaniasis (VL) is a major parasitic childhood disease in sub-Saharan Africa. Expensive and toxic anti-leishmanial drugs are current control methods. Safe, effective and cheap vaccines are potentially powerful strategies to control VL. Traditional vaccine development techniques have failed to deliver an effective vaccine. Leishmania vaccine development may benefit from immunoinformatics tools. This paper describes an improved in silico prediction method for immunogenic Leishmania donovani donovani GP63 protein T cell epitopes as VL candidate vaccines.                                                                                                                             

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